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Posted June 24, 2008 by publisher in Cuban Healthcare

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Reuters

Cuban scientists said on Tuesday the first vaccine to extend lives of lung cancer patients has been approved by Cuban authorities for use and is available in the island’s hospitals.

The drug, CimaVax EGF, has been shown to increase survival rates on average four to five months and much longer in some patients, they said in a news conference at Cuba’s Center of Molecular Immunology.

In contrast to chemotherapy, the traditional treatment for lung cancer, they said CimaVax EGF has few side effects because it is a modified protein that attacks only cancer cells.

They said it was the first lung cancer vaccine to be approved anywhere in the world, although there are others currently being tested.

“It’s the first vaccine for lung cancer registered in the world,” said Gisela Gonzalez, who headed the development of the vaccine, begun in 1992.

The drug is in various stages of clinical trials in a number of other countries and is most likely to be approved next in Peru, where it could be publicly available by year’s end, Gonzalez said.

She said several private companies had been licensed to market the vaccine, but it will be produced in Cuba. Cost for the treatment had not yet been determined, Gonzalez said.

Other cancer vaccines under development elsewhere include one made by Antigenics Inc against melanoma, the deadliest form of skin cancer, and another made by Avant Immunotherapeutics Inc and licensed by drug giant Pfizer Inc that attacks glioblastoma multiforme, the most common and deadly type of brain tumor.

FOREIGNERS WELCOME

Tania Crombet, director of clinical investigations at Havana’s molecular immunology center, said people from outside Cuba can come to the island for treatment.

“It’s possible to provide this vaccine to any patient, because it’s available in Cuba, it’s approved by the Cuban drug agency so we can market the vaccine in Cuba and we can receive patients from outside,” she said.

The exception would probably be Americans, she said, who are restricted from Cuba travel by the U.S. trade embargo against Cuba in place since 1962.

“Even though there is a new therapeutic tool approved in Cuba they probably wouldn’t be able to come to Cuba to receive it because of the embargo,” Crombet said.

The drug has been approved for clinical trial in the United States, but its possible use there is at least two to three years away, Gonzalez said.

Cuba’s state-run biotechnology sector includes around 50 research and development centers and is considered one of the most advanced in the developing world.

  1. Follow up post #1 added on June 26, 2008 by Hosam

    Is it possible in any way to get the Vaccine overseas? I am living in Jordan and my relative in an urgent ned for this drug. How can I get it?
    How long does the treatment take?


  2. Follow up post #2 added on June 26, 2008 by publisher with 3905 total posts

    Try this company http://www.cubanacan.cu/ they deal with medical tourism to Cuba.



    Cuba consulting services

  3. Follow up post #3 added on June 27, 2008 by ilir

    please can somebody inform me with the name of the company that is going to sell this drug, i live in Albania, my uncle is too ill.  please help me…


  4. Follow up post #4 added on June 27, 2008 by publisher with 3905 total posts

    By Mary Murray | NBC News Havana Bureau Chief

    A Cuban Scientific Research Institute just patented a promising new drug that it says helps terminal lung cancer patients live longer.

    In some cases, the drug known as CimaVax EGF extended the lives of participants in the treatment trials by close to a year.

    CimaVax EGF, is classified as a therapeutic vaccine, because it is composed of modified proteins that help the body recognize and destroy cancer cells for those already suffering from lung cancer. It does not prevent lung cancer.

    “It is the first lung cancer vaccine to be patented in the world,” said Dr. Gisela Gonzalez, head of the team that researched and developed the drug through testing with hundreds of patients over 16 years.

    She did point out that other countries are working on similar vaccines, but that they are still in the development stage.

    Gonzalez cautioned that while it is “not a miracle drug,” she does believe it is a “breakthrough in treating terminally ill patients.”


    While the research team would not identify any side effects of CimaVax EFG, Gonzalez claims it has numerous advantages over traditional treatments alone. Patients breathe easier, experience less fatigue, less pain and increased appetite. It is administered in conjunction with conventional treatments of chemo and radiotherapy.

    CimaVax EGF is undergoing testing in other countries.

    After Cuba concluded the Phase One study that determined safe dosage and the best way to administer the vaccine, Phase Two trials started in Cuba, Canada and England, said Gonzalez. This August additional ones begin in China and Peru. Already the vaccine is being registered in Malaysia for sale in Europe.

    While testing has been approved by the U.S. government, clinical studies may not begin for at least two years.

    The Phase Two studies that were conducted in Cuba and elsewhere took a look at how much longer patients lived with CimaVax EGF as compared to other treatments. Those given the vaccine lived on average 11.47 months compared to 5.33 months for terminal patients treated with only chemotherapy and/or radiation. In the best case scenarios, some fortunate patients lived for up to 18.53 months while taking the new vaccine, compared to other patients who lived for just 7.55 months while undergoing conventional treatment.

    Given those clinical results, Cuba started Phase Three studies in the hope that CimaVax EGF could become the new standard of care in treating end stage lung cancer.

    About 4,500 new cases of lung cancer are diagnosed annually in Cuba while the disease claims over 1.3 million deaths worldwide annually, with the highest rates in the United States, Canada and Europe.

    Across the globe, lungs are the most common site of fatal cancers for both women and men. Lung cancer generally affects people over 50 who have a history of smoking, although other risk factors include exposure to second hand tobacco smoke or pollutant emissions from cars or factories.

    CimaVax EGF could also prove effective in slowing other cancers, believes Dr. Tania Crombet, the team’s chief clinical researcher at Havana’s Center for Molecular Immunology. She said that researchers have begun testing CimaVax EGF’s effectiveness against breast, prostate, uterus and pancreas cancers.

    Crombet also said CimaVax EGF is now available in Cuban hospitals for any patient, regardless of nationality. “We can market the vaccine in Cuba and receive patients from outside.”

    And that could mean an influx of fresh, hard currency for the struggling island’s economy.

    With more than 7,000 scientists dedicated to researching new drugs, Cuba has one of the most sophisticated biotech industries in the developing world. Last year the country earned $350 million from exporting 180 different medicines.



    Cuba consulting services

  5. Follow up post #5 added on June 28, 2008 by Emanuele Braico

    I would like to know where this vaccine will be avalaible in Europe.
    If if is possible to purchase it or if the person that needs treatment must travel to Cuba and have the vaccine done. It is for a patient in Poland.
    Do you sell it over there.
    Thanks for any info
    .(JavaScript must be enabled to view this email address)


  6. Follow up post #6 added on June 28, 2008 by Emanuele Braico

    Also I would like to know, being CimaVax EGF a vaccine, if it is one time shoot or if it is like chemion that you need to take it severla times.
    Please any info or help you can give me would be great.
    .(JavaScript must be enabled to view this email address)


  7. Follow up post #7 added on June 29, 2008 by Emanuele Braico

    Also I would like to know, being CimaVax EGF a vaccine, if it is one time shoot or if it is like chemio that you need several cycles.
    Please any info or help you can give me would be great.
    If anyone out there as any info please contact me on my email:

    .(JavaScript must be enabled to view this email address)

    Thanks,
    Emanuele


  8. Follow up post #8 added on June 30, 2008 by Emanuele Braico

    IF ANYBODY IS READING THIS BLOGS CAN PLEASE SEND ME SOME INFO IM INTERESTED IN THIS VACCINE FOR A PATIENT WITH NSCLC (NON SMALL CELL LUNG CANCER)
    Please let me know at:
    .(JavaScript must be enabled to view this email address)


  9. Follow up post #9 added on July 01, 2008 by Thomas Siby

    how can one get this medicine to India?
    how good is this medicine for a patient suffering from lung cancer as primary and having secondaries on bone and brain?


  10. Follow up post #10 added on July 01, 2008 by publisher with 3905 total posts

    It’s hard to get any objective news or medicine exports out of Cuba. Also, since Cuba’s biotechnology system is not open for inspection, we have no way of knowing what their standards are or how accurate their testing or reporting is.

    Just because you read this, doesn’t mean you can get the drug or even that it works.



    Cuba consulting services

  11. Follow up post #11 added on July 02, 2008 by abu shuriki

    I wish every success to all peeople there.If anybody knows more information about this medicine,a phone number or an address,please send it to me. 
    or any other way to get in toych with them.

    .(JavaScript must be enabled to view this email address)


  12. Follow up post #12 added on July 02, 2008 by Jessica F Prada

    Can you please e-mail info on how to get treatment for my dad? he lives in Peru and has lung cancer (stage 4, small cell) He was diagnosed 10 days ago and is about to start treatment, please help!


  13. Follow up post #13 added on July 12, 2008 by Attila

    Hi my grandmother has lung cancer and she needs this injection. i need to know how to get it and who to turn to plese let me know. it is not a problem to travel or money.


  14. Follow up post #14 added on July 20, 2008 by Yulia

    Would you please tell me how much is a treatment ?


  15. Follow up post #15 added on July 22, 2008 by Attila

    Hi my grandmother has lung cancer and she needs this injection. i need to know how to get it and who to turn to plese let me know. it is not a problem to travel or money.  please help dont ignore the email.

    my email address .(JavaScript must be enabled to view this email address)


  16. Follow up post #16 added on July 22, 2008 by publisher with 3905 total posts

    I’m sorry but I don’t have any more information than what is posted here.

    Cuba does have a good biotechnology and pharmaceutical industry but they are not open to international inspections so one should not believe everything they read about Cuba.

    If it sounds too good to be true coming out of Cuba, it is.



    Cuba consulting services

  17. Follow up post #17 added on July 24, 2008 by Dr Elias Issaq - Holy city of Nazareth - Israel

    A very dear friend 52 years old who lives in Hungary suffers from metastatic lung cancer with faild responce to all known treatment . He is realy ill and needs un urgent intervention. Is there a way to get the CimaVax brought to him to Hungary? We are ready to cover all the expences.


  18. Follow up post #18 added on September 01, 2008 by carlos requena

    porfavor ayuda para una madre peruana .
    que tiene cancer


  19. Follow up post #19 added on September 22, 2008 by LILY

    I am from Armenia, and also interested in getting the CimaVax EGF for my aunt. How is it possible to get it or tio send it to Armenia????


  20. Follow up post #20 added on January 20, 2009 by aydogan yazici

    Dear officer,
    How can I get cimaVax EFG drug for my sister? She has bladder cancer ? Is this drug useful for bladder or another cancer or for lung only? Although we would like to see Cuba very much, it is very diffucult to come to Cuba for treatment.
    If there is any solution to obtain this medicine, please infor us.

    Regards.

    Aydogan Yazici   Ankara Turkiye


  21. Follow up post #21 added on February 22, 2009 by publisher with 3905 total posts

    News story just released:

    Terminal lung cancer patients are living longer thanks to the world’s first registered lung cancer vaccine, a leading Cuban scientist says.

    Cuban scientist Dr. Gisela Gonzalez says she and her team have created a lung cancer vaccine that extends patient’s lives.

    Dr. Gisela Gonzalez has spent years researching the vaccine which the Cuban government approved for the use of the general public last year.

    Gonzalez and her team have worked on developing the CimaVax EGF vaccine at the Cuban Center of Molecular Immunology since the early 1990s.

    She says all those years of hard work have finally paid off as trials show that Cubans with lung cancer are living a little longer after having the vaccine.

    “One of my early patients was a 32-year-old man when he started taking the vaccine. I had a son that age,” the scientist told CNN.

    “Now he’s 35. He’s living and working. He visited us the other day and said he’s thinking about having kids.”

    Gonzalez says that more than 700 patients have received the vaccine over the years, many of them in seven clinical trials in Cuba, Canada and the UK.

    More than 400 advanced lung cancer patients received the Vaccine CimaVax EGF in the trials, according to the Latin American News Agency.

    The trials showed that the drug extended the life of terminal patients by an average of four months, and in some cases several years, compared with those patients who only received traditional therapies. Younger patients tended to fare better.

    “It has the potential to be very important,” according to Dr. Howard Burris, director of drug development at the Sarah Cannon Research Institute in Nashville, Tennessee.

    He said the results were comparable to those being produced by two other lung cancer vaccines, GVAX and BLP 25, being developed in the United States.

    “Larger trials will show there are subsets that it’s very good for and for others it’s not relevant,” he said.

    CimaVax EGF does not prevent or cure lung cancer…

    Read the rest of the story



    Cuba consulting services

  22. Follow up post #22 added on March 13, 2009 by DAVID VEGA

    NEED INFORMATION ON CUBAN BLADDER CANCER DRUGS AND TREATMENTs


  23. Follow up post #23 added on March 30, 2009 by marle mountis

    we need information regarding the new vaccine… my uncle is seriously ill with lung cancer that has metastasis at his bones. he suffers from pains etc.. we are in cyprus and are in need of this vaccine. please come back with info on how we can purchase it.. thank you


  24. Follow up post #24 added on April 15, 2009 by NNS

    Many many thanks to anyone who could tell me where or how get this Cimavax vaccine !!! Please help to help !!!


  25. Follow up post #25 added on April 15, 2009 by NNS

    Many many thanks to anyone who could tell me where or how get this Cimavax vaccine !!! Please help to help !!! 
    .(JavaScript must be enabled to view this email address)


  26. Follow up post #26 added on October 21, 2009 by mariposa

    Por favor necesito comprar esta vacuna, estoy dispuesta a viajar a Cuba. Diganme como la consigo.
    Please I need to purchase this vaccines as soon as possible, is there anyone who can tell me where to get it?? I could travel to Cuba as well if necesary, this is for a family member….please help!!!


  27. Follow up post #27 added on December 12, 2009 by Manas

    Dear Sir/Madam,
    He is my father, 77 yrs old. please guide me if CIMAVAX EGF will be available in India.

    Seriat sections have been taken through the entire thoracic region and displayed on soft tissue
    and lung window settings,
    The mediastinal vascular structures are well identified and appear smooth in outline.
    No significant lymph node enlargement is seen’
    The trachea and its bifurcation are normal.
    There is a lobulated necrotic rnass with spiculated outline, measuring 59x4omm in the
    feft infra-hilar I vertebral region. Specks of calcification are also noted within the
    mass. Associated small pleural effusion is also seen on this area’
    The left upper tobe shows hyperinflation. Few fibrotic strands are also noted in the
    basal segments on left side.-imall ill defined opacities are also seen in the right upper
    and lower lobes.
    There is no pleural effusion on the right side. The bony cage is intact’
    Sections obtained through the upper abdomen show a well marginated cyst in the liver,
    segment V. Incidental note is made of a hiatus hernia’
    IMPRESSION:
    THE FINDINGS ARE SUGGESTIVE OF A MITOTIC IDROCESS IN THE LEFT INFRA-HILAR


  28. Follow up post #28 added on January 28, 2010 by ipicmed

    Estimados amigos, nosotros somos el Instituto Peruano de Investigación en Ciencias Médicas de Lima - Peru y venimos tratando a pacientes con cancer de pulmón de celulas no pequeñas en estadio avanzado con un tratamiento novedoso: la vacuna cimavax-EGF que es una vacuna terapeutica (ocasiona la produccion de autoanticuerpos contra la enfermedad) desarrollada en Cuba que por el momento solo esta disponible en ese pais y en el Perú; con la que vemos resultados bastante favorables con nuestros pacientes con cancer de pulmon, incluso en algunos que han recibido segunda y tercera linea de tratamiento quimioterapico.
    Si desean mayor información sobre este tratamiento pueden solicitarla a .(JavaScript must be enabled to view this email address) gustosamente les explicaremos segun sea el caso.

    IPICMED
    LIMA PERU


  29. Follow up post #29 added on January 12, 2011 by Zoltan Kiss

    Dear Madame / Sir,
    Can anyone help me how to get the Cimavax-EGF?
    I think my Mother needs is very much.
    How can we buy the vaccines?
    If anyone can help, please.
    Zoltan from Hungary


  30. Follow up post #30 added on January 12, 2011 by Zoltan Kiss

    Dear Madame / Sir,
    Can anyone help me how to get the Cimavax-EGF?
    I think my Mother needs is very much.
    How can we buy the vaccines?
    If anyone can help, please.
    Zoltan from Hungary


  31. Follow up post #31 added on January 12, 2011 by Margarete

    I`m from Portugal and have a 30 years old cousin with cancer. Can anyone tell me how to get the vaccine? Even if we have to go to Cuba or anywhere else in the world.

    .(JavaScript must be enabled to view this email address)


  32. Follow up post #32 added on February 20, 2011 by usoario

    the medicine can be obtained by every one who needs it, after presenting the necessary studies of the patient or go there by himself. i met a women from europe which went to cuba in january and was provided with the medicine, after they made her some studies and the additional ones she provided. good luck to every one and keep in mind that there are a lot of efficient treatments which can help you and your relatives, around the world, without being harmful for the body itself!


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